| Table of all A. thaliana MYB genes | Some general references | |
| (a listing of all AtMYB genes with AGI genecode, synonyms, GenEMBL accessions, and gene-specific references) |
(access to a local version of the NCBI BLAST tool to query our protein, cDNA, and genomic sequences; |
| MYB factors represent a family of proteins which include a conserved domain, the MYB DNA-binding domain. In contrast to animals, plants contain a MYB protein subfamily which is characterised by the R2R3-type MYB domain. The 'classical' MYB factors, which are related to c-Myb, seem to be involved in the control of the cell cycle in animals, plants and other higher eukaryotes. Systematic screens for knock-out mutations in MYB genes followed by phenotypic analyses, and the analysis of mutants with interesting phenotypes, have begun to unravel the functions of the 125 R2R3-MYB genes in Arabidopsis thaliana. R2R3-type MYB genes control many aspects of plant secondary metabolism, as well as the identity and fate of plant cells. The first MYB gene identified was the 'oncogene' v-Myb from the avian MYeloBlastosis virus. This gene appears to have originated from a vertebrate gene by capture and subsequent modification. Many vertebrates contain three genes related to v-Myb (c-Myb, A-Myb and B-Myb), and other similar genes were identified in insects, plants, fungi and slime moulds. The encoded proteins are crucial to the control of proliferation and differentiation in a number of cell types and share the conserved MYB DNA-binding domain. This domain generally consists of up to three imperfect repeats, each forming a helix-turn-helix structure of about 53 amino acids. Characteristic of a MYB repeat are three regularly spaced tryptophan residues which form a tryptophan cluster in the three-dimensional helix-turn-helix structure. The three repeats from c-Myb are referred to as R1, R2 and R3. Repeats from other MYB proteins are categorized according to their similarity to either R1, R2 or R3. |
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(Text from COPB 4: 447-456; 2001)
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super-imposition of two animal MYB DNA-binding domains
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